Tripelene
Injectable Solution
For Veterinary Use
Composition:
Each 1 ml contains: 
Tripelennamine HCl: 20 mg (equivalent to 17.5 mg Tripelennamine base).
Properties:
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Tripelennamine HCl is an ethylenediamine-derivative antihistamine (H1 receptor antagonist).
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Antihistamine (H1 receptor antagonist) competitively inhibits histamine at H1 receptor sites.
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It does not inactivate or prevent the release of histamine.
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It prevents the histamine action on the cell.
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Also Tripelennamine has a moderate stimulant activity and minimal anti-cholinergic activity.
Indications:
Antihistaminics are used to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as CNS stimulant in “Downer cows” when administered slow IV.
Target species:
Cattle and horses
Dosage & administration:
Cattle & Horses: 2.5 ml / 45 kg B.Wt.
Treatment may be repeated in 6-12 hours if necessary.
It administered: Warm the solution near to the body temperature
In Cattle: by IV (for rapid action) or IM
In Horses: by IM only.
Warnings & Precautions:
- Central nervous system stimulation in the form of hyperexcitability, nervousness, and muscle tremors lasting up to 20 minutes have been noted in horses, particularly following I.V.I. , only the intramuscular route should be used in horses.
- Over-dosage may give rise to excitement, ataxia, and convulsions.
- Depression of the central nervous system and in-coordination may occur when the drug is used at therapeutic dose levels.
- Disturbances in gastrointestinal function may occur in some instances.
- While poisonous snake bites have been treated with antihistaminic drugs, other conjunctive therapy is required because of toxic reactions associated with the protein complex of venom.
- Do not use in horses intended for food purposes.
Contra-indication:
Don’t administer Tripelennamine IV in horses.
Side effects: none
Withdrawal periods
Cattle:
Meat: 4 days
Milk: 24 hours.
Packing: 10 ml, 25 ml, 30ml, 50 ml & 100 ml vials
